| 产品详情 |
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| Product Name | IWP-4 |
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| Description | Purity >95% by HPLC. IWP-4 is a potent inhibitor of Wnt production that blocks Wnt pathway activity in vitro (IC50 = 25 nM). IWP-4 inactivates Porcupine (porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 MM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of Beta-catenin. IWP-4 has been used to induce cardiomyocyte differentiation from human pluripotent stem cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-acetamide |
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| Gene, Accession, CAS # | CAS: 686772-17-8 |
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| Catalog # | LS-H3208 |
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| Order / More Info | IWP-4 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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