| 产品详情 |
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| Product Name | IWP-2-V2 |
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| Description | Purity >98%. Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to Beta-catenin activation of gene transcription. IWP-2 is an inhibitor of Wnt production (IC50 = 27 nM) that inactivates porcupine, a membrane-bound O-acyltransferase whose palmitoylation activity is essential for the signaling ability and secretion of Wnt proteins. IWP-2-V2 is a less potent IWP-2 derivative whose chemical structure retains the benzothiazole group of its parent compound. It has been used to determine which structural features of IWP-2 are essential for impairing Wnt/Beta-catenin pathway activity. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-4-oxo-3-(phenylmethyl)thieno[3,2-d]pyrimidin-2-yl]thio]-acetamide, Inhibitor of Wnt Production-2-V2 |
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| Gene, Accession, CAS # | CAS: 877618-79-6 |
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| Catalog # | LS-H8275 |
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| Price | |
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| Order / More Info | IWP-2-V2 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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