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| Product Name | IWR-1-exo |
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| Description | Purity >98%. Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to Beta-catenin activation of gene transcription. IWR-1-exo is a diastereomer of IWR-1-endo, the potent inhibitor of the Wnt response. Whereas IWR-1-endo strongly blocks cell-based Wnt/Beta-catenin pathway reporter response (IC50 = 180 nM)4 and suppresses Wnt-dependent zebrafish tail fin regeneration (0.5 µM), IWR-1-exo has little effect in either assay at 10 µM. Thus, this compound is an ideal control for tests involving the active form, IWR-1-endo. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-benzamide |
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| Gene, Accession, CAS # | CAS: 1127442-87-8 |
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| Catalog # | LS-H8278 |
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| Price | |
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| Order / More Info | IWR-1-exo from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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