| 产品详情 |
| Edit |   |
|---|
| Product Name | IWR-1 (IWR-1-endo) |
|---|
| Description | Purity ≥98%. Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3β. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3β. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay). Synonyms: rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide |
|---|
| Size | 5mg, 25mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide |
|---|
| Gene, Accession, CAS # | CAS: 1127442-82-3 |
|---|
| Catalog # | 44963 |
|---|
| Price | |
|---|
| Order / More Info | IWR-1 (IWR-1-endo) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|