| 产品详情 |
| Edit |   |
|---|
| Product Name | VX-702 |
|---|
| Description | Purity >95%. VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38Alpha and p38Beta (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1Beta, and TNF-Alpha production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml, respectively. VX-702, at 1 µM, inhibits activation of p38 in platelets by thrombin, U-46619 , or collagen but does not block platelet aggregation in response to collagen. Although orally active, VX-702 provides only transient suppression of biomarkers of inflammation in ongoing rheumatoid arthritis. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 6-[(aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide |
|---|
| Gene, Accession, CAS # | CAS: 745833-23-2 |
|---|
| Catalog # | LS-H10475 |
|---|
| Price | |
|---|
| Order / More Info | VX-702 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|