| 产品详情 |
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| Product Name | VX-745 |
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| Description | Purity >98%. p38Alpha is a member of the mitogen-activated protein kinase (MAPK) family of serine/threonine protein kinases. It is widely expressed in endothelial, immune, and inflammatory cells and plays a central role in the regulation of proinflammatory cytokine production including TNF-Alpha, IL-1Beta, and IL-6. VX-745 is a potent inhibitor of p38Alpha MAPK (IC50 = 10 nM) with 20-fold selectivity over p38Beta and 1000-fold selectivity over closely related kinases, ERK1 and JNK1-3. It blocks IL-1Beta and TNF-Alpha release in whole blood in vitro with IC50 values of 150 and 180 nM, respectively. VX-745 has been shown to demonstrate anti-inflammatory efficacy in an animal model of rheumatoid arthritis, but was discontinued in clinical trial due to adverse central nervous system effects. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one |
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| Gene, Accession, CAS # | CAS: 209410-46-8 |
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| Catalog # | LS-H10476 |
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| Price | |
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| Order / More Info | VX-745 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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