| 产品详情 |
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| Product Name | Beta-Catenin/Tcf Inhibitor VI, ICG-001 |
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| Description | Purity ~99% (HPLC). A cell-permeable pyrazinopyrimidinecarboxamide that competes against beta-catenin for CBP (CREB-binding protein) binding and selectively prevents CBP- but not p300-, dependent TCF/beta-catenin transcriptional regulations both in cultures in vitro (5 to 25uM) and in mice in vivo (5mg/kg/day via osmotic pump infusion), while not affecting CBP-dependent transcriptional activities mediated by the AP-1 or CRE complex. Shown to reactivate p300//TCF/beta-catenin-mediated neuronal differentiation upon NGF stimulation in PS-1 L286V mutant-expressing PC-12 cultures and be efficacious in alleviating bleomycin- (0,08 units/50 uL/mouse; administered intranasally) induced pulmonary fibrosis in mice. Solubility: DMSO Primary Target: CREB-binding protein |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Beta-Catenin/Tcf Inhibitor VI, ICG-001 ((6S,9aS)-Hexahydro-6-((4-hydroxyphenyl)methyl)-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide, (6S)-N-Benzyl-6-(p-hydroxyphenylmethyl)-8-(1-naphthylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, ICG001, Wnt Pathway Inhibitor XX) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217217 |
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| Order / More Info | Beta-Catenin/Tcf Inhibitor VI, ICG-001 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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