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| Product Name | TIGAR, Recombinant, Human, TAT-tag (TP53-Induced Glycolysis and Apoptosis Regulator) |
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| Description | Purity ~95% (SDS-PAGE). TIGAR is a p53-inducible enzyme that catalyzes the hydrolysis of fructose-2-6 bisphosphate (F-2-6-BP) to fructose-6-phosphate and inorganic phosphate. F-2-6-BP is a powerful activator of 6-phosphofructose-1 kinase, the rate limiting enzyme of glycolysis. By lowering the intracellular level of F-2-6-BP, TIGAR expression leads to increased glucose processing via the pentose phosphate pathway, the major cellular source for NADPH. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors and other intracellular proteins into primary as well as transformed cells. Source: Recombinant protein corresponding to 283aa residues, including 269aa residues from full-length human TIGAR, fused to a 14aa residue C-terminal peptide TAT-tag containing the transduction domain (GGGYGRKKRRQRRR), expressed in E. coli. Molecular Weight: ~31.6kD Endotoxin: <0.1ng/ug of protein (<1EU/ug) AA Sequence: ARFALTVVRH GETRFNKEKI I |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TP53-induced glycolysis and apoptosis regulator |
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| Gene, Accession, CAS # | TIGAR, Gene ID: 57103, SwissProt: Q9NQ88 |
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| Catalog # | 220331 |
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| Order / More Info | TIGAR, Recombinant, Human, TAT-tag (TP53-Induced Glycolysis and Apoptosis Regulator) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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