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| Product Name | TIGAR, Recombinant, Human (TP53-induced Glycolysis and Apoptosis Regulator) |
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| Description | Purity ~95% (SDS-PAGE). TIGAR is a p53-inducible enzyme that catalyzes the hydrolysis of fructose-2-6 bisphosphate (F-2-6-BP) to fructose-6-phosphate and inorganic phosphate. F-2-6-BP is a powerful activator of 6-phosphofructose-1 kinase, the rate limiting enzyme of glycolysis. By lowering the intracellular level of F-2-6-BP, TIGAR expression leads to increased glucose processing via the pentose phosphate pathway, the major cellular source for NADPH. Source: Recombinant protein corresponding to 269aa residues from human TIGAR, expressed in E. coli. Molecular Weight: ~29.9kD Endotoxin: <0.1ng/ug of protein (<1EU/ug) AA Sequence: ARFALTVVRH GETRFNKEKI IQGQGVDEPL SETGFKQAAA AGIFLNNVKF THAFSSDLMR TKQTMHGILE RSKFCKDMTV KYDSRLRERK YGVVEGKALS ELRAMAKAAR EECPVFTPPG GETLDQVKMR GIDFFEFLCQ LILKEADQKE QFSQGSPSNC LETSLAEIFP LGKNHSSKVN SDSGIPGLAA SVLVVSHGAY MRSLFDYFLT DLKCSLPATL SRSELMSVTP NTGMSLFIIN FEEGREVKPT VQCICMNLQD HLNGLTETR |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TP53-induced glycolysis and apoptosis regulator (TIGAR) |
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| Gene, Accession, CAS # | TIGAR, Gene ID: 57103, SwissProt: Q9NQ88 |
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| Catalog # | 220330 |
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| Order / More Info | TIGAR, Recombinant, Human (TP53-induced Glycolysis and Apoptosis Regulator) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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