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| Product Name | Thyroid Peroxidase, IgG, BioAssay™ ELISA Kit (Human) (TPO) |
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| Description | Thyroid peroxidase (TPO) is the major autoantigen (933aa residue) in the thyroid microsomal antigen (TMA) particle. Detection of TPO antibodies is strong evidence against a goiter or non-autoimmune causes of hypothyroidism. The annual risk for the development of hypothyroidism is 3% to 4% per year if TPO antibodies are present and TSH is elevated. TPO antibodies are present in 8-9% normal controls, 57-74% patients with Graves disease, 99-100% of Hashimoto disease or idiopathic myxedema, 19% with differentiated thyroid cancer, and 11% of those with other miscellaneous non-autoimmune thyroid diseases. The prevalence of positive TPO antibodies is higher in elderly (mean age 80 years) women (10%) compared to elderly men (2%). Autoantibody concentration in centenarians also decreases. Studies of TPO epitopes in each domain, A and B, and detection of their specific autoantibodies suggest that the epitope-specific TPO antibodies ratio (A/B) does not change over time in individual patients and |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 301294 |
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| Order / More Info | Thyroid Peroxidase, IgG, BioAssay™ ELISA Kit (Human) (TPO) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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