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| Product Name | Thyroid Peroxidase, Recombinant, Human (TPO, TMA, Thyroid Microsomal Antigen) |
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| Description | Purity ≥95% (SDS-PAGE). Thyroid Peroxidase (TPO) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. Its identity with the formerly so-called `microsomal antigen` has been shown several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two identical subunits of approx. 100kD molecular weight. The hemoprotein TPO plays a key role in the thyroid hormone biosynthesis by catalysing both the iodination of tyrosyl residues and the coupling of iodotyrosyl residues in thyroglobulin (TG) to form precursors of the thyroid hormones T4 and T3. Recombinant Human TPO produced in SF9 is a glycosylated, polypeptide chain coding for the extracellular domain of native TPO, containing 834 amino acids and having a molecular mass of 92,872 dalton. Recombinant TPO is expressed with a -6xHis tag and purified by proprietary chromatographic techniques. Immunological Functions: 1. |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | T5399-04R |
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| Order / More Info | Thyroid Peroxidase, Recombinant, Human (TPO, TMA, Thyroid Microsomal Antigen) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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