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| Product Name | Human Leptin receptor Fc tag Recombinant (LEPR) |
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| Description | MW: 132,494 Da. Purity >98%, as determined by SDS-PAGE and HPLC. Leptin exerts its activity through specific membrane receptor, the obesity or leptin receptor (LEP-R), which is assigned to class I cytokine receptor family. Six splice variants of LEP-R have been identified up to now; a long isoform, four short isoforms discriminated by the different lengths of intracellular domain and the secreted isoform, which modulates blood leptin. According to the current knowledge, leptin-signaling pathway |
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| Size | 0.02 mg, 0.1 mg, 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Human Leptin receptor Fc tag Recombinant; leptin; lepr] |
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| Gene, Accession, CAS # | LEPR, Gene ID: 3953, Accession: NP_001003679.1 |
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| Catalog # | MBS553334 |
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| Order / More Info | Human Leptin receptor Fc tag Recombinant (LEPR) from MYBIOSOURCE INC. |
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| Product Specific References | • acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic c57blks/j- LEPRdb/ LEPRdb mice .Cancer Prevention Research, Jan 2011; 4: 128 - 136. • the triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and LEPRdb/db mice .J. Biol. Chem., Dec 2010; 285: 40581 - 40592. • leptin receptor (LEPR) is a negative modulator of bone mechanosensitivity and genetic variation |
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