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| Product Name | Neurofilament-L Blocking Peptide |
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| Description | Highly Purified. Peptide is used to block Neurofilament-L Rabbit mAb reactivity in immunohistochemistry protocols. The cytoskeleton consists of three types of cytosolic fibers: actin microfilaments, intermediate filaments and microtubules. Neurofilaments are the major intermediate filaments found in neurons and consist of light (NFL), medium (NFM) and heavy (NFH) subunits (1). Similar in structure to other intermediate filament proteins, neurofilaments have a globular amino-terminal head, a central α-helical rod domain and a carboxy-terminal tail. A heterotetrameric unit (NFL-NFM and NFL-NFH) forms a protofilament, with eight protofilaments comprising the typical 10 nm intermediate filament (2). Neurofilaments are critical for radial axon growth and determine axon caliber while microtubules are involved in axon elongation. PKA phosphorylates the head domain of NFL and NFM to inhibit neurofilament assembly (3-4). Accumulation of neurofilaments are found in many human neurological |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | IHC |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | N2155 |
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| Order / More Info | Neurofilament-L Blocking Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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