| 产品详情 |
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| Product Name | PIP3 Antagonist II, DM-PIT-1 |
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| Description | Purity ~98% (HPLC). A cell-permeable benzoylthiourea compound that is shown to compete against PIP3 for binding PH domains of Akt1 (IC50 >31uM), ARNO, GRP1, and P1. Effectively blocks PIP3-dependent cellular PI3K-PDK1-Akt signaling pathway activation in U87MG (25 to 100uM for 3d) and PDGF-induced Akt and GRP membrane translocation in serum-starved SUM159 cells (1h 100uM pretreatment), while being inactive against PDGF-induced Btk translocation or PMA-induced PLC-delta and TAPP1/2 translocations. Although DM-PIT-1 can be administered as a DMSO stock for effective culture treatments, incorporating DM-PIT-1 into PEG-PE mixed micelles enhances its solubility (up to 1mM) and i.v. dosing limit for more effective in vivo administrations (5% vs. 41% of control 4T1 tumor size in mice via 1mg/kg micelles-formulated or 0.4mg/kg free drug daily i.v., respectively). Formula: C16H15N3O4S Molecular Weight: 345.4 Solubility: DMSO (25mg/ml) |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PIP3 Antagonist II, DM-PIT-1, N-((2-Hydroxy-5-nitrophenyl)carbamothioyl)-3,5-dimethylbenzamide, N-(((2-Hydroxy-5-nitrophenyl)amino)thioxomethyl)-3,5-dimethyl-benzamide, Akt Inhibitor XXII, PDK1 Inhibitor VI) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217665 |
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| Order / More Info | PIP3 Antagonist II, DM-PIT-1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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