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| Product Name | Proprotein Convertase 9, Recombinant Human |
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| Description | Purity ≥ 95% by SDSPAGE under reducing conditions and visualized by silver stain. Endotoxin: ≤ 1.0 EU/1ug (LAL). The human PCSK9 gene encodes Proprotein Convertase 9 (PC9), which is also known as Neural Apoptosis- Regulated Convertase 1 (NARC1). The deduced aa sequence of human PCSK9 consists of a signal peptide (residues 1-30), a pro peptide (residue 31-152), and a mature chain (residues 153-692) that contains a serine protease domain (residues 161-431) found in members of the furin/PC family. PCSK9 protease activity may be limited, since it has only been demonstrated through its own autocatalytic processing. After the autocleavage in the ER, the pro domain and mature chain exit the cell together through non-covalent interactions. PCSK9 is a key regulator of LDL- cholesterol levels (LDL-C) through binding LDL receptor, resulting in reduction of receptor recycling to the cell surface and acceleration of receptor degradation in lysosomes. Both gain-of-function (GOF) and loss-of- functi |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Proprotein Convertase 9, Recombinant Human (PCSK9, Proprotein Convertase Subtilisin/Kexin Type 9, FH3, HCHOLA3, LDLCQ1, NARC1, NARC-1, Neural Apoptosis-regulated Convertase 1, PC9, PSEC0052, Subtilisin/kexin-like Protease PC9) |
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| Gene, Accession, CAS # | SwissProt: Q8NBP7 |
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| Catalog # | P9052-29A |
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| Price | |
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| Order / More Info | Proprotein Convertase 9, Recombinant Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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