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| Product Name | Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), BioAssay™ ELISA Kit (Human) |
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| Description | Proprotein convertase subtilisin/kexin type 9, also known as PCSK9, is an enzyme that in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. By genomic sequence analysis, the PCSK9 gene was mapped to chromosome 1p32. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A(EGF-A) domain of the low-density lipoprotein receptor(LDLR), inducing LDLR degradation. Reduced LDLR levels result in decreased metabolism of low-density lipoproteins(LDL), which could lead to hypercholesterolemia. PCSK9 may also have a role in the differentiation of cortical neurons. Intended Use: This kit is intended for the quantitative determination of human PCSK9 in cell culture supernatants, cell lysates, tissue homogenates, serum and plasma (heparin, EDTA). Detection Range: 156-10,000pg/ml Sensitivity: <10pg/ml Precision: Intra-assay: <10% |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 255738, SwissProt: Q8NBP7 |
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| Catalog # | 353008 |
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| Order / More Info | Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), BioAssay™ ELISA Kit (Human) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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