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| Product Name | Interleukin-33, active (IL33), Recombinant, Human |
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| Description | Purity ≥97% as determined by SDS-PAGE and HPLC. Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an alarmin, that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). (ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:17853410, ECO:0000269|PubMed:18836528).; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100). (ECO:0000269|PubMe |
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| Size | 2ug, 10ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL-33, IL-1F11, Nuclear factor from high endothelial venules, NF-HEV, |
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| Gene, Accession, CAS # | IL33_HUMAN, SwissProt: O95760 |
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| Catalog # | 348126 |
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| Order / More Info | Interleukin-33, active (IL33), Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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