| 产品详情 |
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| Product Name | Interleukin-33, active (Il33), Recombinant, Mouse |
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| Description | Purity ≥98% as determined by SDS-PAGE and HPLC. Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an alarmin, that amplifies immune responses during tissue injury.; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.5ng/ml, corresponding to a spe |
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| Size | 2ug, 10ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL-33 |
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| Gene, Accession, CAS # | IL33_MOUSE, SwissProt: Q8BVZ5 |
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| Catalog # | 348127 |
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| Order / More Info | Interleukin-33, active (Il33), Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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