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| Product Name | UNC2170 (maleate) |
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| Description | Purity >95%. p53-Binding protein 1 (53BP1) binds to dimethylated lysine 20 on histone 4 (H4K20me2) via tandem tudor domains on a 53BP1 homodimer. This interaction is an important part of the DNA damage response. UNC2170 is a micromolar ligand of 53BP1 that binds to a pocket formed by the tandem tudor domains. It displays at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. UNC2170 functions as a 53BP1 antagonist in cellular lysates and shows cellular activity by suppressing class switch recombination, a process which requires a functional 53BP1 tudor domain. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]-benzamide, 2Z-butenedioate |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H10378 |
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| Price | |
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| Order / More Info | UNC2170 (maleate) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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