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| Product Name | Interferon lambda-1, active (IFNL1), Recombinant, Human |
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| Description | Purity ≥97% as determined by SDS-PAGE and HPLC. Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is less than 5ng/ml, corresponding to a specific activity of 2.0x10e5 IU/ |
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| Size | 5ug, 20ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IFN-lambda-1, Interleukin-29, IL-29 |
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| Gene, Accession, CAS # | IFNL1_HUMAN, SwissProt: Q8IU54 |
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| Catalog # | 348087 |
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| Price | |
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| Order / More Info | Interferon lambda-1, active (IFNL1), Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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