| 产品详情 |
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| Product Name | Apicidin |
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| Description | Purity ≥ 95% by HPLC. Apicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. Apicidin, a histone deacetylase inhibitor, is anti-angiogenic and induces apoptosis. A potent, cell permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC50 = 50 - 100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF-10A cells possibly by down regulating MMP-2 in a reversible manner. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. Apicidin induces selective changes in the expression of p21 and gelsolin. Applications: Suitable for use as a histone deacetylase inhibitor. Other applications have not been tested |
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| Size | 2mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]; Cyclo(8-oxo-L-2-aminodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-D-2-piperidinecarbonyl); Apicidin Ia; OSI 2040 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | A2298-79 |
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| Price | |
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| Order / More Info | Apicidin from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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