| 产品详情 |
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| Product Name | MBIMPH |
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| Description | Purity >98% by HPLC. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =9nM). Displays high selectivity over all other HDACs (IC50=0.1-12µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-Hydroxy-4-((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)benzamide |
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| Gene, Accession, CAS # | CAS: 1392835-53-8 |
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| Catalog # | LS-H690 |
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| Price | |
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| Order / More Info | MBIMPH from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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