| 产品详情 |
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| Product Name | Longdaysin |
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| Description | Purity ~99% (HPLC). A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIa and CKId activities (IC50 = 5.6 and 8.8uM) with moderate selectivity over Cdk7 and Erk2 (IC50 = 29 and 52uM). Shown to block CKIa/d-mediated phosphorylation of PER1, a clock protein, (IC50 ~9uM) and repress PER1 proteasomal degradation, and lengthen the circadian period in U2OS cells (by ~13hrs at 10uM) much more effectively than Casein Kinase I Inhibitor, D4476 and IC261 and in larval zebra fish. Formula: C16H16F3N5 Molecular Weight: 335.3 Solubility: DMSO (50mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Longdaysin (Casein Kinase I Inhibitor VII, 9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217514 |
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| Price | |
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| Order / More Info | Longdaysin from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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| 产品资料 |
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