| 产品详情 |
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| Product Name | Calphostin C |
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| Description | Purity >95%. Calphostin C is a metabolite of the fungus C. cladosporioides that specifically inhibits protein kinase C (PKC) (IC50 = 50 nM versus an IC50 > 50 µM for PKA) by competing at the binding site for diacylglycerol and phorbol esters. As a polycyclic hydrocarbon with strong absorbance in the visible and ultraviolet ranges, activation of this compound is strictly dependent on exposure to light. Independent of PKC, calphostin C also directly inhibits phospholipase D1 and D2 (IC50 s = 100 nM). It demonstrates antitumor activity, inhibiting cell growth and promoting apoptosis in HeLa S3 and MCF-7 cells with IC50 values of 0.23 and 0.18 µM, respectively. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethyl 4-carbonic acid, UCN 1028C, Cladochrome E, PKF 115-584 |
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| Gene, Accession, CAS # | CAS: 121263-19-2 |
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| Catalog # | LS-H6973 |
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| Price | |
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| Order / More Info | Calphostin C from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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