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| Product Name | Recombinant Human Transcription intermediary factor 1-beta protein |
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| Description | 22-291aa; Partial. MW: 56.1kD. Purity >90% as determined by SDS-PAGE. Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 an |
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| Size | 0.01 mg, 0.05 mg, 0.1 mg, 0.2 mg, 0.5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [E3 SUMO-protein ligase TRIM28 (EC:6.3.2.-); KRAB-associated protein 1; KAP-1; KRAB-interacting protein 1; KRIP-1; Nuclear corepressor KAP-1; RING finger protein 96; Tripartite motif-containing protein 28] |
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| Gene, Accession, CAS # | TRIM28, Gene ID: 10155, Accession: NP_005753.1 |
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| Catalog # | MBS717118 |
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| Order / More Info | Recombinant Human Transcription intermediary factor 1-beta protein from MYBIOSOURCE INC. |
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| Product Specific References | KAP-1, a novel corepressor for the highly conserved KRAB repression domain.Friedman J.R., Fredericks W.J., Jensen D.E., Speicher D.W., Huang X.-P., Neilson E.G., Rauscher F.J. IIIGenes Dev. 10:2067-2078(1996) Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.Moosmann P.R., Georgiev O., le Douarin B., Bourquin J.-P., Schaffner W.Nucleic Acids Res. 24:4859-4867(1996) Emison E.S., Lewis B.C., Shim H., Li Q., Dang C.V., Lee L.A. Bienven |
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