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| Product Name | Interleukin 33, Recombinant, Human (IL-33) |
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| Description | Purity ≥95% by SDS PAGE. Interleukin 33 (IL-33) is a 32kD proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kD and C-terminal fragment of 18kD by cleavage of caspase-1. Recombinant human IL-33(C-terminal fragment) was expressed in E. coli and purified by using conventional chromatography techniques. Molecular Weight: 18kD (160 amino acids) Sequences: MSITGISPIT/ EYLASLSTYN/ DQSITFALED/ ESYEIYVEDL/ KKDEKKDKVL/ LSYYESQHPS/ NESGDGVDGK/ MLMVTLSPTK/ DFWLHANNKE/ HSVELHKCEK/ PLPDQAFF |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | I7663-97 |
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| Order / More Info | Interleukin 33, Recombinant, Human (IL-33) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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