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| Product Name | GABA Receptor B R2, Rat, Control Peptide (Gamma-aminobutyric Acid Receptor Type B) |
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| Description | GABA (g-amino butyric acid) is the most abundant neurotransmitter in mammalian brain. GABA exerts its effects through ionotropic ligand-gated GABAA, GABAC and GABAB receptors (GABABRs). Presynaptic GABABRs inhibit neurotransmitter release by down regulating high voltage activated, Ca+2 channels, whereas postsynaptic GABABRs decrease neuronal excitability by activating a prominent inwardly rectifying K+ (Kir) conductance that underlies the late inhibitory postsynaptic potential. Two N-terminal splice variants of GABABR1 (also called GBR1), GABABR1a (GBR1a, rat 960aa, apparent mol wt ~130kD; human 961aa) and GABABR1b (GBR1b; rat 844aa, apparent mol. wt 100kD; human 844aa) have been cloned and characterized. Human and rat GBR1a and GBR1b share 99% sequence homology. GABABRs are characterized by the presence of a cleavable signal peptide, a large extracellular N-terminus, 7 TM domains, and C-terminal, cytoplasmic domain. GABABRs are expressed in all major areas of the brain. Recently GABAB |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | G1015-50R |
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| Order / More Info | GABA Receptor B R2, Rat, Control Peptide (Gamma-aminobutyric Acid Receptor Type B) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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