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| Product Name | FG-4592 |
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| Description | Purity >98%. The hypoxia-inducible factor (HIF) pathway alters gene expression in response to low oxygen tension. Under normoxic conditions, HIF-specific prolyl hydroxylases (HIF-PHs) initiate the degradation of oxygen-sensitive HIF isoforms. As 2-oxoglutarate (2-OG) is a required co-factor for HIF-PH activity, analogs of 2-OG may inhibit HIF-PH and prevent HIF turnover. FG-4592 is an analog of 2-OG that has been developed as an inhibitor of HIF-PHs. While little has been published regarding the actions of this compound, similar HIF-PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression, promoting erythropoiesis or preventing anemia in vivo . |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-glycine, ASP1517, Roxadustat |
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| Gene, Accession, CAS # | CAS: 808118-40-3 |
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| Catalog # | LS-H7783 |
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| Price | |
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| Order / More Info | FG-4592 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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