| 产品详情 |
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| Antigenic Specificity | MDC1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | biotin conjugate |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MDC1 Antibody (Biotin) LS-C500933. Specificity: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. |
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| Immunogen | Recombinant Human Mediator of DNA damage checkpoint protein 1 protein (1892-2082AA) |
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| Other Names | MDC1, Em:AB023051.5, NFBD1, KIAA0170 |
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| Gene, Accession # | MDC1, Gene ID: 9656 |
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| Catalog # | LS-C500933 |
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| Price | |
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| Order / More Info | MDC1 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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