| 产品详情 |
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| Product Name | Dithiothreitol (DTT) |
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| Description | Purity ≥98%. Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent. DTT's oxidized form is a disulfide-bonded 6-membered ring. Its name derives from the four-carbon sugar, threose. DTT has an epimeric ('sister') compound, dithioerythritol (DTE). DTT is an unusually strong reducing agent, owing to its high conformational propensity to form a six-membered ring with an internal disulfide bond. It has a redox potential of -0.33 V at pH 7. The reduction of a typical disulfide bond proceeds by two sequential thiol-disulfide exchange reactions and is illustrated below. The intermediate mixed-disulfide state is unstable (i.e., poorly populated) because the second thiol of DTT has a high propensity to close the ring, forming oxidized DTT and leaving behind a reduced disulfide bond. The reducing power of DTT is limited to pH values above ~7, since only the negatively charged thiolate form -S- is reactive (the protonated thiol form -SH is not); the |
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| Size | 10g, 25g, 50g |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Cleland's reagent;; (2R,3R)-rel-1,4-Dimercapto-2,3-butanediol; (±)-1,4-Dimercapto-2,3-butanediol; (±)-Dithiothreitol; 1,4-Dithio-DL-threitol; 1,4-Dithiothreitol; DL-1,4-Dimercapto-2,3-dihydroxybutane; DL-1,4-Dithiothreitol; DL-Dithiothreitol; Sputolysin; WR 34678; threo-1,4-Dimercapto-2,3-butanediol; threo-2,3-Dihydroxy-1,4-butanedithiol; threo-2,3-Dihydroxy-1,4-dithiolbutane |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | D8070 |
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| Order / More Info | Dithiothreitol (DTT) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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