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| Product Name | Interleukin 31 Receptor A, Recombinant, Human (IL-31RA, gp130-Like Monocyte Receptor, GLM-R, GPL) |
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| Description | Purity ≥ 95%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin ≤ 1EU. The interleukin-31 receptor A subunit (IL-31 RA), also known as gp130-Like Monocyte Receptor (GLM-R or GPL), is a ~100kD type I transmembrane glycoprotein that is classified as being a type I cytokine receptor (1, 2). A heterodimeric complex of IL-31 RA and the oncostatin M receptor (OSM-R) functions as the signaling receptor for IL-31 (3). Both subunits are inducibly expressed throughout the myelomonocytic lineage and are upregulated by interferon- and bacterial lipopolysaccharides (1-3). IL-31 RA is also expressed on keratinocytes, dorsal root ganglia neurons, and variably on lung epithelial cells (3-6). The 732 amino acid (aa) IL-31 RA contains a 19 aa signal sequence, a 500 aa extracellular domain (ECD), a 21 aa transmembrane domain and a 192 aa cytoplasmic domain. The ECD shares 60%, 58%, 73% and 70% aa identity with mouse, rat, dog and cow IL-31 RA ECD, respectively. Human IL-31 receptors do |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q8NI17 |
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| Catalog # | I8442-41F |
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| Order / More Info | Interleukin 31 Receptor A, Recombinant, Human (IL-31RA, gp130-Like Monocyte Receptor, GLM-R, GPL) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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