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| Product Name | SMUG1, Recombinant, Human, aa1-177, His-SUMO-tag |
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| Description | Purity ~90% (SDS-PAGE). Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration. Source: Recombinant protein corresponding to aa1-177 from human SMUG1, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~35.6kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SMUG1, Recombinant, Human, aa1-177, His-SUMO-Tag (Single-strand Selective Monofunctional Uracil DNA Glycosylase) |
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| Gene, Accession, CAS # | SwissProt: Q53HV7 |
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| Catalog # | 375343 |
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| Order / More Info | SMUG1, Recombinant, Human, aa1-177, His-SUMO-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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