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| Product Name | CCG-1423 |
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| Description | Purity >98% by HPLC. CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. CCG-1423 displays activity in several in vitro cancer cell functional assays. CCG-1423 potently (<1 mumol/L) inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells, and whereas it inhibits the growth of RhoC-overexpressing melanoma lines at nanomolar concentrations, it is less active on related lines that express lower levels of Rho. Similarly, CCG-1423 selectively stimulates apoptosis of the metastasis-prone, RhoC-overexpressing melanoma cell line (A375M2) compared with the parental cell line (A375). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[2-[(4-Chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)benzamide |
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| Gene, Accession, CAS # | CAS: 285986-88-1 |
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| Catalog # | LS-H3484 |
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| Order / More Info | CCG-1423 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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