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| Product Name | CCG-1423 |
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| Description | Purity >98%. The Rho family of small GTPases play an important role in transduction of cell signaling events associated with several human cancers. CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. It inhibits SRF-driven luciferase expression in PC-3 cells following stimulation with constitutively active GAlpha13 with an IC50 value of 1 µM. The site of inhibition in the pathway is not precisely defined but CCG-1423 appears to act on some aspect of the interaction of SRF with its transcriptional cofactor megakaryoblastic leukemia 1 (MKL1) at a point upstream of DNA binding. CCG-1423 selectively inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[2-[4(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis (trifluoromethyl)-benzamide |
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| Gene, Accession, CAS # | CAS: 285986-88-1 |
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| Catalog # | LS-H7026 |
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| Order / More Info | CCG-1423 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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