| 产品详情 |
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| Product Name | Gliotoxin |
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| Description | Purity >98%. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi. It inhibits 20S proteasomal chymotrypsin activity (IC50 = 10 µM), blocking the degradation of I?BAlpha and preventing the activation of NF-?B. Gliotoxin also induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils. It also inhibits geranylgeranyltransferase I and farnesyltransferase (IC50 = 17 and 80 µM, respectively). Gliotoxin potently suppresses viral infection by Nipah and Hendra virus in vitro (IC50 = 149 and 579 nM, respectively). While gliotoxin production by fungi correlates with invasiveness, its role in aspergillosis remains unclear. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2,3R,5aS,6S-tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10aR-epidithiopyrazino[1,2-a]indole-1,4-dione, Aspergillin, S. N. 12870 |
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| Gene, Accession, CAS # | CAS: 67-99-2 |
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| Catalog # | LS-H7942 |
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| Price | |
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| Order / More Info | Gliotoxin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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