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| Product Name | ITGA4, Recombinant, Human, aa131-275, His-Tag |
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| Description | Purity ~95%. The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha 4 chain associates with either beta 1 or beta 7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha 4 beta 1 and alpha 4 beta 7 is located on the alpha 4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha 4 beta 7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha 4 beta 7, the gut mucosal homing receptor for peripheral T cells. This recombinant protein fragment includes the ligand and monoclonal antibody binding domains; this binding has been tested and verified in ELISA assays. This recombinant protein is recognized PSI antibodies Integrin 4 alpha (IN1) (PSI 4827) and Integrin 4 alpha (IN |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ITGA4, Recombinant, Human, aa131-275, His-Tag (Integrin alpha-4, CD49 Antigen-like Family Member D, Integrin alpha-IV, VLA-4 Subunit alpha, CD49d, MGC90518) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149773 |
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| Price | |
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| Order / More Info | ITGA4, Recombinant, Human, aa131-275, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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