| 产品详情 |
| Edit |   |
|---|
| Product Name | NSC 405020 |
|---|
| Description | Purity >98% by HPLC. NSC-405020 is a membrane type-I matrix metalloproteinase (MT1-MMP) inhibitor that specifically targets the hemopexin (PEX) domain rather than the catalytic domain of MT1-MMP (IC50 >100 Mmol/L). It does not inhibit the catalytic activity of MT1-MMP or MMP-2. NSC-405020 directly interacts with and binds to PEX in a vicinity of Met-328, Arg-330, Asp-376, Met-22 and Ser-470 of the druggable pocket in the full-length MT1-MMP structure, which affects the conformation and flexibility of blades I to IV of the Beta-propeller resulting in the decrease of the PEX-dependent homodimerization of cellular MT1-MMP. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 3,4-Dichloro-N-(1-methylbutyl)benzamide |
|---|
| Gene, Accession, CAS # | CAS: 2044451 |
|---|
| Catalog # | LS-H3238 |
|---|
| Price | |
|---|
| Order / More Info | NSC 405020 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|