| 产品详情 |
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| Product Name | NSC 405020 |
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| Description | Purity >98%. NSC 405020 binds to the hemopexin (PEX) domain of the membrane type-1 matrix metalloproteinase (MT1 -MMP/MMP-14). It disrupts MT1 -MMP homodimerization without affecting its catalytic activity in an assay using the MT1 -MMP CAT domain, which is involved in its tumor promoting function (IC50 > 100 µM). In a mouse tumor xenograft model, it reduces tumor growth through a cell death-independent mechanism when injected intratumorally at a dose of 0.5 mg/kg three times per week for two weeks. NSC 405020 (1 µM) applied to HSC5 cells prevents arsenic-mediated invasion while also decreasing the expression of MT1 -MMP and pERK. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3,4-dichloro-N-(1-methylbutyl)-benzamide |
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| Gene, Accession, CAS # | CAS: 7497-07-6 |
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| Catalog # | LS-H9087 |
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| Price | |
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| Order / More Info | NSC 405020 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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