| 产品详情 |
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| Product Name | NSC 348884 |
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| Description | Purity >98%. Nucleophosmin is a nucleolar phosphoprotein involved in cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, centrosome duplication, and molecular chaperoning. Its activity is dependent on oligomerization at its N-terminal domain, and it is abundantly expressed in tumor and developing cells where it serves to inhibit both cellular differentiation and apoptosis. NSC 348884 is a small molecule that inhibits the formation of nucleophosmin dimers by disrupting a required binding pocket. It can inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N1 ,N1 ,N2 ,N2 -tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine |
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| Gene, Accession, CAS # | CAS: 81624-55-7 |
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| Catalog # | LS-H9086 |
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| Order / More Info | NSC 348884 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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