| 产品详情 |
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| Product Name | NSC 663284 |
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| Description | Purity >98%. Three genes encode dual specificity phosphatases that are Cdc25 homologs. The phosphatases, Cdc25A through C, are proto-oncogenes and are often over-expressed in cancers. NSC 663284 is a potent, cell-permeable, and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC50 = 29, 95, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively). NSC 663284 poorly inhibits other phosphatases, including Vaccinia virus VH1-related (IC50 = 4.0 µM), PTP1B (no inhibition), and the mitogen-activated protein kinase phosphatases (MKP) MKP-1 or -3 (no inhibition). By inhibiting Cdc25 isoforms, NSC 663284 prevents the dephosphorylation and activation of Cdk1 and Cdk2, arrests cells at both G1 and G2 /M phases, and prevents the proliferation of several human tumor cell lines. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione, Cdc25 Phosphatase Inhibitor II, DA-3003-1, SPS8I1 |
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| Gene, Accession, CAS # | CAS: 383907-43-5 |
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| Catalog # | LS-H9092 |
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| Order / More Info | NSC 663284 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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