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| Product Name | NSC 66811 |
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| Description | Purity >95%. NSC 66811 is a potent inhibitor of murine double minute 2 (Mdm2) interaction with p53 by binding Mdm2 (Ki = 120 nM), in this way activating p53. NSC 66811 induces the accumulation of p21, p53, and Mdm2 in human colon cancer cells in vitro . Inhibitors of the Mdm2-p53 interaction, including NSC 66811, induce p53- and p21-dependent cell cycle arrest and p53-dependent cell death in tumor cell lines. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol |
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| Gene, Accession, CAS # | CAS: 6964-62-1 |
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| Catalog # | LS-H9096 |
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| Order / More Info | NSC 66811 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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