| 产品详情 |
| Edit |   |
|---|
| Product Name | Interleukin-36 receptor antagonist, active (IL36RN), Recombinant, Human |
|---|
| Description | Purity ≥95% as determined by SDS-PAGE and HPLC. Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. (ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23147407). Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-36 beta induced IL-8 secretion by human preadipocytes is less than 1.0ug/ml, corresponding to a specific activity of 1000 IU/mg in the presence of 20ng/ml of recombinant human IL-36 beta. |
|---|
| Size | 5ug, 25ug, 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | IL-36Ra, IL-1-related protein 3, IL-1RP3, Interleukin-1 HY1, IL-1HY1 |
|---|
| Gene, Accession, CAS # | I36RA_HUMAN, SwissProt: Q9UBH0 |
|---|
| Catalog # | 348139 |
|---|
| Price | |
|---|
| Order / More Info | Interleukin-36 receptor antagonist, active (IL36RN), Recombinant, Human from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|