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| Product Name | Interleukin-1 receptor antagonist, active (IL1RN), Recombinant, Human |
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| Description | Purity ≥96% as determined by SDS-PAGE and HPLC. Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. (ECO:0000269|PubMed:7775431). Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1α- dependent proliferation of murine D10S cells is less than 40ng/ml, corresponding to a specific activity of 2.5x10e4 IU/mg in the presence of 50 pg/ml rHuIL-1α. |
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| Size | 20ug, 100ug, 250ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL-1RN, IRAP, ICIL-1RA, IL1 inhibitor, Anakinra |
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| Gene, Accession, CAS # | IL1RA_HUMAN, SwissProt: P18510 |
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| Catalog # | 348097 |
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| Price | |
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| Order / More Info | Interleukin-1 receptor antagonist, active (IL1RN), Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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