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| Product Name | Interleukin-36 receptor antagonist, active (IL36RN), Recombinant, Mouse |
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| Description | Purity ≥95% (SDS-PAGE and HPLC). Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. (ECO:0000269|PubMed:17908936, ECO:0000269|PubMed:18284608, ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679). Biological Activity: Measured by its ability to inhibit IL-36γ induced IL-6 production by human PBMCs. |
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| Size | 2ug, 10ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL-36Ra, IL-1HY1, Interleukin-1 delta, IL-1 delta, Interleukin-1 family member 5 |
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| Gene, Accession, CAS # | I36RA_MOUSE, SwissProt: Q9QYY1 |
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| Catalog # | 348140 |
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| Order / More Info | Interleukin-36 receptor antagonist, active (IL36RN), Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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