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| Product Name | TNFSF11/RANKL BioAssay™ ELISA Kit, Mouse |
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| Description | Sandwich ELISA quantitative detection kit for Mouse TNFSF11/RANKL in cell culture supernates, serum and plasma (heparin, EDTA). Receptor activator of nuclear factor kappa-B ligand(RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), is a protein that in humans is encoded by the TNFSF11 gene. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This gene is mapped to chromosome13q14.11. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. This gene may play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Assay Range: 62.5pg/ml-4000pg/ml Sensitivity: < 10 pg/ml Crossreactivity: |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 21943, SwissProt: O35235 |
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| Catalog # | 144077 |
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| Order / More Info | TNFSF11/RANKL BioAssay™ ELISA Kit, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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