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| Product Name | TNFSF11/RANKL BioAssay™ ELISA Kit (Rat) |
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| Description | Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), is a protein that in humans is encoded by the TNFSF11 gene. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. The rat gene is mapped to 15q11. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. This gene may play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Sample Type: Cell lysates, cell culture supernates, serum, plasma (Heparin or EDTA). Intended Use: Sandwich High Sensitivity BioAssay™ ELISA kit for Quantitative Detection of Rat TNFSF11/RANKL. Sensitivity: <10p |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q9ESE2 |
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| Catalog # | 396801 |
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| Order / More Info | TNFSF11/RANKL BioAssay™ ELISA Kit (Rat) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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