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| Product Name | TNFSF11/RANKL, BioAssay™ ELISA Kit (Human) (Receptor Activator of Nuclear Factor kappa B Ligand) |
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| Description | Receptor activator of nuclear factor kappa-B ligand(RANKL), also known as tumor necrosis factor ligand superfamily member 11(TNFSF11), is a protein that in humans is encoded by the TNFSF11 gene. This gene encodes a member of the tumor necrosis factor(TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This gene is mapped to chromosome13q14.11. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. This gene may play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Sample Type: Cell culture supernates, serum and plasma (heparin, EDTA) Intended Use: For quantitative detection of human TNFSF11 in cell culture supernates, serum and plasma (heparin, EDTA). Sensitivity: |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 8600, SwissProt: O14788 |
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| Catalog # | 353088 |
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| Order / More Info | TNFSF11/RANKL, BioAssay™ ELISA Kit (Human) (Receptor Activator of Nuclear Factor kappa B Ligand) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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