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| Product Name | TNFSF4, Recombinant, Human |
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| Description | Purity ~97% (SDS-PAGE and HPLC). OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ. OX40/OX40L signaling plays an important role in immuno-regulatory communication, enabling the immune system to distinguish between ``friend vs. foe'' during activation; a mechanism typically te |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TNFSF4, Recombinant, Human (Tumor Necrosis Factor Ligand Superfamily Member 4, Glycoprotein Gp34, OX40 Ligand, OX40L, TAX Transcriptionally-activated Glycoprotein 1, CD252, TXGP1) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149661 |
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| Order / More Info | TNFSF4, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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