| 产品详情 |
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| Product Name | YZ9 |
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| Description | Purity >98%. Cells that are rapidly proliferating or hypoxic emphasize glycolysis over oxidative phosphorylation to meet energy needs. During glycolysis, fructose 6-phosphate (F6P) is phosphorylated by 6-phosphofructo-2-kinases (PFKs) to generate fructose 2,6-bisphosphate. As PFK family members also mediate the reverse reaction as fructose 2,6-bisphosphatases, these enzymes are known as PFKFB family members. Notably, PFKFB3 is overexpressed in a wide variety of cancer cell lines. YZ9 is a potent inhibitor of PFKFB3, with an IC50 value of 183 nM in vitro . It avidly competes with F6P at PFKFB3 (Ki = 94 nM). YZ9 is also cell permeable, inhibiting the growth of HeLa cells with a GI50 value of 2.7 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 7-hydroxy-2-ozo-2H-1-benzopyran-3-carboxylic acid, ethyl ester, 7-hydroxycoumarin-3-Carboxylic Acid ethyl ester |
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| Gene, Accession, CAS # | CAS: 6093-71-6 |
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| Catalog # | LS-H10547 |
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| Price | |
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| Order / More Info | YZ9 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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