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| Product Name | Frizzled5 Fc Chimera, Recombinant Human |
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| Description | Purity ~95% (SDS-PAGE). Frizzled5 is an ~62kD seventransmembrane (7TM) glycoprotein that is one of at least ten Frizzled family Wnt receptors (1 3). Frizzled proteins are thought to be G proteincoupled (1). Wnt engagement of Frizzled, with low density lipoprotein receptorrelated proteins LRP5 or LRP6 acting as coreceptors, stabilizes B-catenin and promotes gene transcription that is important in development and tissue maintenance (1). LRP independent or ``noncanonical'' Frizzled signaling pathways also exist (1). Human Frizzled5 cDNA encodes 585 amino acids (aa) including a 26 aa signal peptide, a 212 aa extracellular domain (ECD), the 7TM region (aa 213 521), and a Cterminal cytoplasmic domain with a PDZ binding motif (aa 522 585) (2, 5). The ECD includes a cysteinerich region (CRD, aa 29 156) that binds Wnts and is highly conserved among Frizzleds (1, 2, 4). Human Frizzled5 shares 95%, 95% and 96% aa identity with mouse, rat and canine Frizzled5, respectively, within the Nterminal extr |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_003459 |
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| Catalog # | F6401-04G |
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| Order / More Info | Frizzled5 Fc Chimera, Recombinant Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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